Nick Kyrgios, Ashleigh Barty, San Stosur and Daria Gavrilova lived up to their Wimbledon seedings overnight to give Australia a flying start in London.

Barty overcame first-round butterflies to finally break her main-draw duck at The All England Club with a 7-5 6-3 win over Swiss Stefanie Voegele.

Gavrilova was equally impressive in seeing off American lucky loser Caroline Dolehide 6-2 6-3 in little more than an hour.

Stosur will decide Gavrilova’s fate after setting up an all-Australian, second-round clash after defeating China’s Peng Shuai 6-4 7-5 in 82 minutes.

And Kyrgios admitted there was nothing comfortable about his tight first-round 7-6 (7-3) 7-6 (7-4) 6-7 (5-7) 6-3 Wimbledon win over Denis Istomin on Tuesday night.

Prevailing when needed in the tiebreakers, Australia’s top title hope in the men’s singles needed 42 aces to see the back of the Uzbeki and safely progress to round two.

“Very tough match. I didn’t play anywhere near my best tennis today,” Kyrgios said.

“I served well, but I struggled to find rhythm. That’s what he does so well on the grass court.

Kyrgios also brought a ballgirl to tears when one of his trademark power serves struck her arm, but endeared himself to fans by quickly rushing to comfort her.

Nick Kyrgios consoles the injured ballgirl. Photo: Getty

Unable to make inroads on his opponent’s serve for much of the match, Kyrgios relied on his own biggest weapon to eke out victory and edge towards a possible third-round showdown with resurgent countryman Bernard Tomic.

“On the grass, he’s a nightmare,” Kyrgios said of Australia’s fellow former Wimbledon quarter-finalist.

“He plays very well on the grass. If he puts his mind to it, he can do some damage here, for sure. I saw how he played today. He looks comfortable.”

A lucky loser from qualifying, Tomic was untroubled in taking out Polish world No.122 Hubert Hurkacz in straight sets, 6-4 6-2 7-6 (7-2), to tee up a date with 24th seed Kei Nishikori.

Kyrgios next faces Dutchman Robin Haase as he continues his quest to make the second week for the fourth time in five visits to the All England Club.

Barty, who took care of Voegele comfortably in straight sets en route to the title in Nottingham only two weeks ago, faced a stiffer challenge from the world No 93 on Tuesday night as errors flowed from the Australian’s end.

Ashleigh Barty overcame a case of jitters to defeat Switzerland’s Stefanie Vogele in their first-round match. Photo: EPA/AAP

Barty dropped her opening service game of the match on a double-fault, hit straight back to level at 1-1, only to falter again in the seventh game and fall 5-3 behind.

The 17th seed held her nerve, though, to reel off eight consecutive games to snatch the set and then race to a 4-0 lead in the second.

It was all over after 77 minutes as Barty rammed down her seventh ace to book a second-round meeting with either former finalist Eugenie Bouchard, who qualified this year, or British wildcard Gabriella Taylor.

Elsewhere, Australian teen sensation Alex de Minaur’s has knocked French Open semi-finalist Marco Cecchinato out of Wimbledon.

De Minaur, who reached the junior final at The All England two years ago, prevailed 6-4 6-7 (8-6) 7-6 (7-5) 6-4 in an absorbing three-hour slugfest on Court 17.

He’ll now face Pierre-Hugues Herbert in the second round and victory over the Frenchman could potentially set up a third-round match-up with world No.1 Rafael Nadal.

Matthew Ebden stunned world no.9 David Goffin in a straight sets 6-4 6-3 6-4 win.

-With AAP