Two men are on the run after Victorian police officers were attacked and their cars rammed at a petrol station.

Police were called to an Ampol station on Kings Way, South Melbourne, at 3am on Friday with reports of two men slumped in a car.

Both men woke up and attempted to assault the two officers before attempting to flee the scene, police said.

The pair then rammed their car into the two police vehicles that had been parked behind and in front.

It is believed the car also collided with another vehicle on Kings Way and Dorkas Street while fleeing.

At 3.40am, the offenders’ car was located under the West Gate freeway.

One officer received minor injuries in the incident and was treated at the scene.

A police helicopter and the dog squad have joined the search for the men.

– AAP