Police are searching for two people who left the scene of a horror car smash in Melbourne’s south-east that killed one person and left four others in hospital, one in a critical condition.

Six people were travelling in a Kia car with stolen plates on Narre Warren-Cranbourne Road, at Narre Warren South, when the driver ran a red light at high speed, hit another car and flipped the vehicle on Saturday about 7:30pm.

Two males who were in the Kia were flown to hospital with critical injuries. One of them, a 17-year-old Dandenong boy, died about 8:45am today.

A 19-year-old Hampton Park man and a 15-year-old Narre Warren boy were also taken to hospital by road ambulance under police guard.

The driver of the other vehicle, a man aged in his 20s, was also taken to hospital with back pain.

Police said two other people who were in the Kia, an unknown male and female, fled the scene.

They left friends behind

Inspector John Cormack urged witnesses, including anyone who may have filmed the incident on their phone, to come forward.

“Police will be reviewing CCTV of people who have left the scene but we really would like those people to come forward to explain their actions,” he said.

“They have left their friends behind here and they are critically ill, fighting for their lives.

“If you know who these people are, please contact police. We need to know number one that they are OK and we need to speak to them to get a full account of what has happened here.”