A woman is dead and two teenagers have been charged after a fiery crash involving an allegedly stolen ute and three other cars in Adelaide’s south overnight.

Police said a Holden utility was travelling north on the Southern Expressway at about 9.15pm when it collided with three cars on Main South Road at Bedford Park.

In what appeared to be a high-speed collision, at least one car exploded into flames and one of the drivers, a 48-year-old woman from Panorama, died at the scene.

Two other drivers were taken to Flinders Medical Centre in a serious condition.

The driver of the ute, a 15-year-old boy from Sturt, received minor injuries.

Police said he was under guard in hospital and has been charged with aggravated cause death by dangerous driving, illegal use and serious criminal trespass.

He was refused bail.

At least one of the cars exploded into flames . Photo: ABC News.

Police alleged he broke into a house at Onkaparinga Hills and stole the ute.

His passenger, a 17-year-old from Morphett Vale, was charged with illegal use and breach of bail.

He was refused bail and is expected to appear in the Adelaide Youth Court later today.

The start of the Southern Expressway remains closed and traffic is being diverted through the Marion Road exit.

Detours are in place along South Road between Sturt and Flagstaff roads.

Significant road delays are expected and Major Crash investigators are at the scene.