Police are hunting for a killer after a doctor was gunned down in the garage of his Brisbane home.

The 56-year-old general practitioner was shot in the chest about 11.40pm on Monday while packing his car at his MacGregor home.

He was taken to Princess Alexandra Hospital in a critical condition where he died.

The man’s wife and two adult children were at home when the shooting occurred.

The shooter remains at large and it’s believed the pair didn’t know each other.

Police suspect only one person was involved in the shooting but say it could be more.

Detectives are searching for a man in a light-coloured sedan or hatchback.

Police have asked for anyone in the MacGregor area, particularly on Delfin Street bounded by Mains Road and Granadilla Street, to come forward with any CCTV or dash cam footage.

They are unable to say what type of gun was used or at what range the shooter fired from.

The victim worked as a doctor in Brisbane’s Chinese community on the city’s south side.

His wife is an overseas trained doctor, and their two adult children are also studying to become doctors.

-AAP