NSW Police have fatally shot and killed a 46-year-old man after a confrontation in Sydney’s west on Tuesday morning.

Officers visited a home in Seven Hills over an outstanding warrant at about 11.20 am on Tuesday.

In a statement, a NSW Police said officers visited a home on Bulah Way where “a physical confrontation ensued and a man was shot by police.”

Police say them man approached them with a knife and an axe before being shot.

NSW Acting Assistant Commissioner Julie Boon said four officers were in attendance and the shots were fired inside the home.

But she was unable to confirm how many officers discharged their weapon or how many times the man was shot.

“Officers let out a number of shots, unfortunately the man collapsed”, Ms Boon said. They conducted CPR until ambulance paramedics arrived, but the man could not be revived.

“I believe the man was the only person inside the premises at the time, that will come out as part of a critical incident investigation,” she said.

Dozens of police and emergency services were seen in the area after the shooting.

Reports suggest a CareFlight helicopter was seen landing on an oval in Seven Hills near where the shooting occurred.

Several residential streets have also been closed off.

A crime scene has been established and inquiries are underway.

The Law Enforcement Conduct Commission is independently monitoring a review by the NSW Police Professional Standards Command.

– with AAP