A manhunt is underway in western Sydney after a father was stabbed to death by three young men in his own home.

The gang approached the Dharruk residence of Erol Tokcan, 36, on Friday night before threatening and stabbing him in the chest.

Erol Tockan, 36, was attacked by three men in his Dharruk home. Facebook

Mr Tokcan was treated by paramedics at the scene before being taken to hospital, where he later died.

Distraught relatives arrived at the home to find it sealed by police tape as a crime scene was set up.

Footage of the street showed one woman screaming “where’s my brother?” before breaking down and being comforted by officers.

“F*** this area! F*** Mount Druitt,” she yelled.

Another woman, believed to be Mr Tokcan’s partner, was also inconsolable.

“He’s going to die if they don’t hurry up,” she yelled at police.

“I love you, Erol, think about your mum and your sisters.”

Detective Inspector David Goddard said police were trying to establish exactly what happened inside the house and urged witnesses to come forward.

“I get the feeling they went there for a reason,” he told reporters on Saturday.

“I can confidently say people in the community here would know something or heard something.”

Mr Tokcan’s school friend, Nader Mahmud, 42, was one of the last people to visit him before the attack.

He described Mr Tokcan as a kind-hearted, giving person who was “a bit of a rough head” at school but never started trouble.

“Erol, since I’ve known him, has always had a big heart – a big lion heart,” he told AAP.

“He protected me all my life. He protected so many of his friends around this area.”

Several neighbours reported hearing the young men cheering as they fled, while others say they threw around a step ladder before leaving.

Mr Tokcan, who had a young daughter, had previously survived a serious motorbike accident.

Police spent much of Saturday combing the street and speaking with neighbours.

No arrests had been made on Saturday evening and Det Insp Goddard urged the culprits to hand themselves in.

“We will track you down,” he said.

-AAP