NSW police officers from the organised crime squad have uncovered several drug labs and seized large amounts of illicit drugs in a blitz across the state over the weekend.

Police from Strike Force Brinkley seized pill press machines, precursor chemicals, ammunition, steroids and one kilogram of a substance believed to be MDMA from several properties in Sydney.

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Four litres of methylamphetamine oil and 142 MDMA pills were found at one clan lab, while another 143 MDMA pills were found at a Menai home, along with 50 rounds of pistol ammunition.

A 40-year-old man from Sydney and a 34-year-old man from Hawks Nest were arrested and charged with large commercial drug manufacturing offences and have been refused bail.

The Commander of the Organised Crime Squad, Detective Superintendent Scott Cook said the labs were capable of producing large amounts of amphetamine-type substances.

“By shutting this laboratory down, we are confident we have prevented hundreds of kilograms of drugs from hitting the streets,” Det Supt Cook said.

“Organised crime groups continue to invest heavily in the manufacture and supply of illicit drugs.”

Two large drugs labs were uncovered in industrial units in Milperra and Mount Druitt, while properties in Menai, Eastlakes and Nabiac were searched.

Strike Force Brinkley continues to investigate the activities of organised crime groups and syndicates in Sydney.