Two men have been charged after a neighbourhood dispute in Sydney’s southwest left four people in hospital including at least two with serious stab wounds.

A 16-year-old boy was stabbed seven times including in his stomach, left forearm, left thigh, chest and back during the brawl at Treuer Parade in Yagoona on Sunday afternoon.

The boy’s 24-year-old sister was left with a seven-centimetre cut to the left side of her head, stab wounds to the left armpit and above right knee, and a small cut to her left eyelid.

The boy and his sister were taken to Liverpool Hospital where they were in a serious but stable condition.

A 20-year-old man was admitted to Westmead Hospital, where he remains under police guard while being treated for an injury to his left arm, while a 44-year-old woman is also under police guard in Bankstown Hospital, where she is receiving treatment for fractures to her nose and eye.

Two men, including a 23-year-old and his 47-year-old father, were arrested at the scene.

The 23-year-old and 47-year-old have both been charged with wound person with intent to cause grievous bodily harm.

The older man has been additionally charged with affray and reckless grievous bodily harm in company.

Both men were set to appear in Bankstown Local Court on Monday.