An Australian warship has seized heroin worth more than $150 million from a smuggling vessel off the east coast of Africa.

It was the second time in two months the frigate HMAS Toowoomba has been responsible for a big drug haul.

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In the latest bust, Toowoomba on Monday intercepted a vessel in international waters carrying about 388 kilograms of heroin.

The haul, which had an estimated Australian street value of $155 million, was subsequently dumped in the ocean.

It was part of an international campaign to disrupt Indian Ocean drug smuggling, which helps fund terrorist organisations.

In September a boarding party from Toowoomba found 5.6 tonnes of cannabis on a smuggling ship off Somalia.