George Clooney has whisked his new bride off to the Seychelles for a luxury honeymoon, according to reports.

The US movie star and his new wife, Amal Alamuddin, are said to be enjoying a special vacation on a private island which is only accessible by helicopter.

Reports suggest Clooney has rented out a luxury villa on North Island for more than $US5,000 ($A5,409)-per person, per night.

The exclusive resort has previously hosted Clooney’s friend Brad Pitt and Angelina Jolie, as well as Prince William and the Duchess of Cambridge.

Clooney wed Alamuddin in Venice on September 27 and the nuptials were made official during a civil service on September 29.