Several streets have been locked down in inner Melbourne near Crown Casino as police search for a man wanted in relation to an early morning shooting.

Police were called to Queensbridge Street, Southbank, at about 4.15am on Thursday after being called to a shooting incident.

No-one was injured, Nine Network reported.

A large police presence was at the scene well into the morning, with dozens of officers scouring the area as they continue their investigation. A crime scene has been established.

It is understood a man is on the run, brandishing a hand gun on Melbourne’s fringe.

Police closed off Power Street between Queensbridge Street and City Road.

Anyone who witnessed the incident or with any information is urged to contact Crime Stoppers on 1800 333 000.