An education department employee from Adelaide is among five people arrested for allegedly running a drug laboratory in a hotel where illegal firearms were found.

Police on Wednesday informed the South Australian Department of Education and Child Development (SAECD) that the woman, who is facing drug and firearms charges, was an employee at a metropolitan school.

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Officers discovered the clandestine drug laboratory and suspected methamphetamine in an Adelaide hotel room bathroom on Monday, where they also found two homemade pen guns and ammunition.

A 52-year-old woman from Oakden, a 26-year-old woman and a 33-year-old woman, both of no fixed address, a 29-year-old Redwood Park man and a 35-year-old Royal Park man, were all arrested and charged with drug manufacturing and trafficking, possessing a firearm without a licence and possessing insecure ammunition.

SAECD said the woman has been told not to come to work, but it would not name the school she worked at.