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‘New day’ in treatment of heart failure

A new study reports one of the biggest potential advances against heart failure in more than a decade – a first-of-a-kind, experimental drug that lowered the chances of death or hospitalisation by about 20 per cent.

Doctors say the Novartis drug – which doesn’t have a name yet – seems like one of those rare, breakthrough therapies that could quickly change care for more than half of the 24 million people worldwide with heart failure.

“This is a new day” for patients, said Dr Clyde Yancy, cardiology chief at Northwestern University in Chicago and a former American Heart Association president.

“It’s been at least a decade since we’ve had a breakthrough of this magnitude,” said Yancy, who had no role in the study.

It involved nearly 8500 people in 47 countries and was the largest experiment ever done in heart failure. It was paid for, designed and partly run by Novartis, based in Basel, Switzerland.

Independent monitors stopped the study in April, seven months earlier than planned, when it was clear the drug was better than an older one that is standard now.

During the 27-month study, the Novartis drug cut the chances of dying of heart-related causes by 20 per cent and for any reason by 16 per cent, compared to the older drug. It also reduced the risk of being hospitalised for heart failure by 21 per cent.

“We are really excited,” said one study leader, Dr Milton Packer of UT Southwestern Medical Center in Dallas. The benefit “exceeded our original expectations.”

Results were disclosed on Saturday at a European Society of Cardiology conference in Barcelona and published online by the New England Journal of Medicine.

Novartis will seek approval for the drug – for now called LCZ696 – by the end of this year in the United States and early next year in Europe.

Heart failure is the top reason older people are hospitalised, and a leading cause of death.

It develops when the heart muscle weakens over time and can no longer pump effectively, often because of damage from a heart attack. Fluid can back up into the lungs and leave people gasping for breath.

The new drug is a twice-a-day pill combination of two medicines that block the effects of substances that harm the heart while also preserving ones that help protect it. One of the medicines also dilates blood vessels and allows the heart to pump more effectively.

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