2DayFM radio host Mel Greig has opened up more than a year after her disastrous prank phone call prompted a British nurse to take her own life.

Ms Greig and her co-host, Michael Christian, received global criticism in December 2012 after they made a prank phone call to the hospital where the Duchess of Cambridge had been admitted during her pregnancy.

Posing as the Queen and Prince Charles, the pair asked to be connected to the Duchess’ ward, where she was being treated for acute morning sickness.

The woman who unknowingly connected the call, nurse Jacintha Saldanha, was found hanged three days later, leaving behind a suicide note which blamed the radio hosts.

Jacintha Saldanha

“I am ashamed of myself,” Ms Greig shared during an interview with Channel Seven’s Sunday Night last night. “I should have tried harder to not let that prank call air.”

Ms Greig revealed on last night’s program that she had asked radio bosses to alter the call before it went to air, suggesting they sub out the voice of the real nurse for those of radio staffers.

“I felt like a failure as a human being,” Ms Greig, who resigned after the scandal, admitted.

In the aftermath of the tragedy, Ms Greig also revealed she had suffered from depression and dealt with death threats to her family.

“They would call my mum and say ‘an eye for an eye – she died… and now you have to die’.”

When interviewer Mel Doyle asked Ms Greig if she could play the recording of the call, Ms Greig refused.

“I don’t want to ever listen to it again,” she said.

Meanwhile, the career of her co-host Mr Christian has remained relatively unscathed. Last year, he was awarded the title of “next top jock” by Southern Cross Austereo bosses.

After being temporarily suspended following the prank, Mr Christian was moved into Melbourne’s Fox FM mornings timeslot.

Ms Greig remains unemployed.